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Updated: Feb 10, 2026

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
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Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration

Denise Karaoglu Hanzatian1, Annette Schwartz2, Farid Gizatullin1

  • 1a AbbVie Bioresearch Center , 381 Plantation St., Worcester , MA.

Mabs
|May 18, 2018
PubMed
Summary

Dual-variable-domain immunoglobulin (DVD-Ig) proteins enhance brain uptake by utilizing the transferrin receptor 1 (TfR1) pathway. This novel approach improves delivery of therapeutics across the blood-brain barrier (BBB) for central nervous system (CNS) applications.

Keywords:
bispecific antibodiesblood-brain barrier (BBB)brain uptake of antibodiesdual variable domain immunoglobulinreceptor-mediated transcytosis

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