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The vasodilator effect of human atrial natriuretic factor (99-126) on human omental arteries
G Bruschi1, M E Bruschi, G Orlandini
1Istituto di Clinica Medica e Nefrologia, Università di Parma, Italy.
Abstract:
The effect of synthetic human atrial natriuretic factor [ANF-(99-126)] on human omental arteries was investigated. The compound produced concentration-dependent relaxation, 10, 50 and 90% of maximum effect being observed at about 1, 10 and 100 nmol/l, respectively. These concentrations are considerably higher than those measured by radio-immunoassay in human plasma, even under extreme conditions (0.001-0.3 nmol/l). Therefore, ANF can dilate human resistance-size arteries, but whether it does so under physiological conditions has not been established.