Related Experiment Video

Updated: Feb 10, 2026

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

Published on: November 28, 2010

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Nature of tumour rejection antigens in ovarian cancer

Muzamil Y Want1, Amit A Lugade1, Sebastiano Battaglia1

  • 1Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Immunology
|May 18, 2018
PubMed

Insights

Identifying cancer-testis antigens and neoantigens in ovarian cancer is key for developing effective immunotherapies. This research focuses on selecting tumor rejection antigens to enhance T-cell-mediated cancer cell destruction.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Molecular characterization of human tumor antigens has advanced cancer immunotherapy.
  • Cancer-testis (CT) antigens are extensively studied in ovarian cancer due to their immunogenicity and restricted expression.
  • Elucidating tumor recognition mechanisms accelerates the development of immune-mediated tumor rejection strategies.

Purpose of the Study:

  • To review current strategies for selecting tumor rejection antigens in ovarian cancer.
  • To highlight the potential of neoantigens as specific immune targets for ovarian cancer immunotherapy.
  • To improve the efficacy of immunotherapy by identifying optimal immune targets.

Main Methods:

  • Review of preclinical and clinical studies on cancer-testis antigens in ovarian cancer.
  • Analysis of recent advancements in cancer sequencing technologies for neoantigen identification.
  • Evaluation of methods for selecting tumor mutations likely to be recognized by the immune system.

Main Results:

  • Cancer-testis antigens are promising targets for ovarian cancer immunotherapy.
  • Tumor mutations (neoantigens) identified through advanced sequencing can serve as specific immune targets.
  • Selection of appropriate tumor rejection antigens is crucial for enhancing immunotherapy efficacy.

Conclusions:

  • Targeting cancer-testis antigens and neoantigens holds significant potential for ovarian cancer treatment.
  • Advances in sequencing technologies enable precise identification of targets for T-cell-mediated tumor destruction.
  • Further research in selecting tumor rejection antigens will improve immunotherapy outcomes in ovarian cancer.
Keywords:
antigenimmunotherapynext-generation sequencingovarian cancer

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