Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Motion Of A Charged Particle In A Magnetic Field01:22

Motion Of A Charged Particle In A Magnetic Field

7.2K
A charged particle experiences a force when moving through a magnetic field. Consider the field to be uniform and the charged particle to move perpendicular to it. If the field is in a vacuum, the magnetic field is the dominant factor determining the motion. Since the magnetic force is perpendicular to the direction of motion, a charged particle follows a curved path. The particle continues to follow this curved path until it forms a complete circle. Another way to look at this is that the...
7.2K
Subatomic Particles03:37

Subatomic Particles

113.8K
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
113.8K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

9.1K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
9.1K
Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

14.6K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
14.6K
The Nucleosome Core Particle01:12

The Nucleosome Core Particle

2.4K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[<i>Longsha Kaihe Liuqi</i> acupuncture in treatment of primary open angle glaucoma: a randomized controlled trial].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2026
Same author

Endoplasmic reticulum, mitochondria, and their crosstalk in retinal ganglion cell degeneration.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Hemoglobin mediates the link between the 'weekend warrior' physical activity pattern and diabetic retinopathy.

Scientific reports·2025
Same author

Evaluation of Auricular Acupressure on Myopia Prevention among Children Aged 6-12 Years with Pre-Myopia in China: Study Protocol of a Prospective Multi-Center Randomized Controlled Trial.

Complementary medicine research·2025
Same author

Predictive role of the peripheral blood inflammation indices neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immunoinflammatory index (SII) for age-related cataract risk.

PloS one·2024
Same author

Association between dietary inflammatory index and adolescent myopia based on the National Health and Nutrition Examination Survey.

Scientific reports·2024

Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: A Novel Method for Comprehensive Cell Component Analysis of Cerebral Blood Clots
06:12

Author Spotlight: A Novel Method for Comprehensive Cell Component Analysis of Cerebral Blood Clots

Published on: July 21, 2023

1.1K

Evaluating blood clot progression using magnetic particle spectroscopy.

Hafsa Khurshid1,2, Yipeng Shi3, Brent L Berwin4

  • 1Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA.

Medical Physics
|May 18, 2018
PubMed
Summary

Magnetic nanoparticle relaxation time can predict blood clot age and organization, enabling earlier diagnosis of conditions like stroke and deep vein thrombosis. This minimally invasive method offers a promising new diagnostic tool.

Keywords:
magnetic fieldsnanoparticle's imagingquantitative imagingspectroscopic imaging

More Related Videos

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.8K
Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models
06:16

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models

Published on: April 19, 2024

1.8K

Related Experiment Videos

Last Updated: Feb 10, 2026

Author Spotlight: A Novel Method for Comprehensive Cell Component Analysis of Cerebral Blood Clots
06:12

Author Spotlight: A Novel Method for Comprehensive Cell Component Analysis of Cerebral Blood Clots

Published on: July 21, 2023

1.1K
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.8K
Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models
06:16

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models

Published on: April 19, 2024

1.8K

Area of Science:

  • Biophysics
  • Biomaterials Science

Background:

  • Early and accurate diagnosis of thrombotic diseases like stroke, myocardial infarction, and deep vein thrombosis is crucial.
  • Current diagnostic methods for thrombus maturity can be invasive or lack precision.

Purpose of the Study:

  • To noninvasively evaluate thrombus maturity using magnetic nanoparticle properties.
  • To enable earlier and more accurate diagnosis of various thrombotic diseases.

Main Methods:

  • Magnetic spectroscopy of nanoparticle Brownian rotation (MSB) was employed to detect and characterize blood clots.
  • Nanoparticle relaxation time was quantified to assess binding to thrombin on the clot.
  • The number of bound nanoparticles and their binding characteristics were analyzed for clots of varying ages.

Main Results:

  • A decreased relaxation time of bound nanoparticles correlated with more mature and organized clots.
  • The quantity of nanoparticles binding to the clot decreased with increasing clot age.
  • Nanoparticle binding mechanisms differed between mature (surface binding) and developing clots (matrix trapping).

Conclusions:

  • Magnetic nanoparticle relaxation time can predict clot age and organization.
  • The developed method is quick and minimally invasive, suitable for in vivo applications.
  • This technique holds promise for earlier and more accurate diagnosis of thrombotic events.