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Colchicine In Epistenocardiac Pericarditis

Lovely Chhabra, N Gurukripa Kowlgi, David H Spodick

    Connecticut Medicine
    |May 18, 2018
    PubMed

    Insights

    Epistenocardiac pericarditis (EP), a rare post-myocardial infarction (MI) complication, presents treatment challenges. This case series explores colchicine as an alternative therapy for EP when high-dose aspirin is not feasible.

    Area of Science:

    • Cardiology
    • Internal Medicine
    • Clinical Research

    Background:

    • Epistenocardiac pericarditis (EP) is a rare complication occurring early after myocardial infarction (MI).
    • Standard treatment involves high-dose aspirin, but this can be contraindicated with newer antiplatelet agents.
    • The efficacy of colchicine for EP is not well-established, necessitating further investigation.

    Purpose of the Study:

    • To evaluate the efficacy and safety of colchicine in treating epistenocardiac pericarditis (EP).
    • To present a case series of patients with EP treated with colchicine.

    Main Methods:

    • A case series of 11 patients diagnosed with epistenocardiac pericarditis (EP) was retrospectively analyzed.
    • Patients received colchicine for treatment of EP.
    • Clinical outcomes and adverse events were documented.

    Main Results:

    • Colchicine treatment was associated with symptom resolution in the studied EP patients.
    • No major adverse events were reported during colchicine therapy for EP.
    • Further studies are needed to confirm these preliminary findings.

    Conclusions:

    • Colchicine may be a viable alternative treatment for epistenocardiac pericarditis (EP), especially when high-dose aspirin is contraindicated.
    • This case series suggests colchicine is safe and potentially effective for managing EP.
    • Larger, prospective studies are warranted to establish definitive evidence for colchicine in EP treatment.

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