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Related Experiment Video

Updated: Feb 10, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

Common Grounds for Family Maladies.

Konrad Oexle¹, Juliane Winkelmann²

¹Institute of Neurogenomics, Helmholtz Center Munich, Munich, Germany.

|May 18, 2018

Summary

This summary is machine-generated.

Common genetic variants play a larger role in familial migraine than in the general population. This finding advances our understanding of migraine genetics and disease inheritance patterns.

Keywords:

Brugada syndrome HEY2 common disease common variants family aggregation migraine rare disorders rare variants

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Area of Science:

Genetics
Neurology
Disease Etiology

Background:

Rare variants are known to cause Mendelian inheritance in some common diseases.
Common variants are increasingly recognized for their potential contribution to rare diseases.

Purpose of the Study:

To investigate the burden of common genetic variants in familial migraine compared to the general population.
To explore the genetic architecture of migraine.

Main Methods:

Analysis of common variant burden in familial migraine cases.
Comparison with migraine cases from the general population.

Main Results:

The study found a significantly larger burden of common variants in individuals with familial migraine.
This suggests a distinct genetic contribution in familial forms of the disease.

Conclusions:

Common variants contribute substantially to the genetic risk of familial migraine.
Understanding variant burden is crucial for diagnosing and treating migraine disorders.