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Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration
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RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration

Baskar Bakthavachalu1, Joern Huelsmeier2, Indulekha P Sudhakaran1

  • 1National Centre for Biological Sciences, TIFR, Bangalore 560065, India.

Neuron
|May 18, 2018
PubMed
Summary

Intrinsically disordered regions of Ataxin-2 (ATXN2) are crucial for neuronal RNP granule assembly, impacting memory and neurodegeneration. Reducing granule formation may alleviate certain neurodegenerative diseases.

Keywords:
ALSAtaxin-2C9ORF72DrosophilaFUSlong-term memoryneurodegenerationstress granuletherapeutictranslational control

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