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Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Introduction to Lymphatic and Immune System01:22

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
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Functions of the Lymphatic and Immune System01:28

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Lymphatic Vessels and Lymph Transport01:16

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
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Liver Histology01:27

Liver Histology

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Liver Physiology01:30

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Related Experiment Video

Updated: Feb 10, 2026

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
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Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

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Lymphatics in the liver.

Masatake Tanaka1, Yasuko Iwakiri1

  • 1Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Current Opinion in Immunology
|May 18, 2018
PubMed
Summary

The liver produces the most lymph, and its lymphatic vessels increase in disease. This review explores the hepatic lymphatic system

Area of Science:

  • Hepatology and Lymphatic Biology

Background:

  • The liver is the largest lymph-producing organ.
  • Increased hepatic lymphatic vessels (lymphangiogenesis) are observed in liver diseases like cirrhosis, viral hepatitis, and hepatocellular carcinoma.
  • The hepatic lymphatic system remains understudied despite its apparent importance.

Purpose of the Study:

  • To review current knowledge of the hepatic lymphatic system.
  • To discuss the role of lymphatic endothelial cells in liver health and disease.
  • To outline future research directions for the hepatic lymphatic system.

Main Methods:

  • Literature review incorporating knowledge from lymphatic systems in other organs.
  • Synthesis of existing research on hepatic lymphangiogenesis and lymphatic endothelial cells.
  • Identification of knowledge gaps and future research avenues.

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Related Experiment Videos

Last Updated: Feb 10, 2026

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

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Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

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Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
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Main Results:

  • The liver's lymphatic system plays a crucial role in maintaining liver homeostasis.
  • Lymphangiogenesis is a significant feature in various liver pathologies.
  • Hepatic lymphatic endothelial cells are implicated in disease progression and potential therapeutic targets.

Conclusions:

  • Further research into the hepatic lymphatic system is essential for understanding liver disease.
  • Targeting lymphatic endothelial cells may offer novel therapeutic strategies for liver conditions.
  • A comprehensive understanding of hepatic lymphatics is critical for advancing hepatology.