Related Experiment Video
Updated: Feb 10, 2026

Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure
Published on: August 28, 2009
Myeloid heme oxygenase-1: a new therapeutic target in anti-inflammation
Mingyi Zhao1, Minghua Yang2, Weitao Que3
1Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410006, China.
Abstract:
An increasing amount of evidence reveals that an orchestrated interplay between myeloid subpopulations in the hematopoietic system plays a significant role in supporting normal functions of the immune system and facilitating homeostatic restoration upon exogenous or endogenous insults. Heme oxygenase-1 (HO-1), a microsomal enzyme discovered decades ago, can metabolize pro-oxidant heme into biliverdin, free iron, and carbon monoxide. This enzymatic reaction produces biological materials, contributing to major immunomodulatory effects. Specifically, HO-1 expression in myeloid cells has been generally acknowledged to drive potent anti-inflammatory and immunosuppressive responses. In this review, the authors focused on elucidating the potential mechanisms underlying myeloid HO-mediated immunomodulation phenotypes, and discussed the potential application of myeloid-specific HO-1 induction as an anti-inflammation therapeutic strategy.
Related Concept Videos
Inflammation
Therapeutic Index
Therapeutic Communication
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
Differentiation of Common Myeloid Progenitor Cells
Microorganisms in Medicine and Therapeutics
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...

