Revisiting the "Art of the Chemical Probe"

Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control.

Journal of the American Chemical Society·2026

Malaria Public Health Status: Global Context and Update on Gulf Cooperation Council Countries.

Advances in experimental medicine and biology·2026

Emergence of specific binding and catalysis from a designed generalist binding protein.

Nature chemistry·2026

An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome.

Journal of medicinal chemistry·2026

Survey of the human proteostasis network: the ubiquitin-proteasome system.

bioRxiv : the preprint server for biology·2026

High-Throughput Platform for Discovery of Chemical Inhibitors of Heat Shock Protein 70 (Hsp70): Adaptation for the Specialized Bacterial HscA-HscB-IscU Complex.

Chemical biology & drug design·2026

Exploring the Substrate Selectivity of the Condensation Domain VibH through Engineered Adenylation Domains, Non-Native Amide Synthesis, and Substrate Recognition Analysis.

ACS chemical biology·2026

Exploiting Acquired Drug Resistance in Pancreatic Cancer through Selective Covalent Targeting of MAP2K4/7.

ACS chemical biology·2026

From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main Protease.

ACS chemical biology·2026

A Chemigenetic Ca2+ Indicator Based on a Red Fluorescent Protein and a Synthetic Chelator.

ACS chemical biology·2026

Effective Tumor Protection by a Tumor-Associated Mucin-1 Glycopeptide-Based Conjugate Vaccine in a Spontaneous Mouse Breast Cancer Model.

ACS chemical biology·2026

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds an Fe-S Cluster.

ACS chemical biology·2026

Association of rs10741657 polymorphism in CYP2R1 gene with apparently healthy vitamin-D deficient Pakistani subjects.

JPMA. The Journal of the Pakistan Medical Association·2026

Percutaneous endoscopic lumbar discectomy combined with annular suture versus PELD alone for single-level lumbar disc herniation: A prospective propensity score-matched cohort study.

Journal of orthopaedic surgery (Hong Kong)·2026

Impact of spasmolytic cocktail and Glidesheath Slender on radial artery spasm in transradial cerebral angiography: A randomized factorial trial.

Journal of vascular and interventional radiology : JVIR·2026

Frustrated Interfacial Solvation Enhances Reaction Rates at Acidified Ice Grain Boundaries in Frozen Microdroplets.

Journal of the American Chemical Society·2026

Probing the Quantum Nature of Intramolecular Vibrational Energy Redistribution in HCCH-H2CC Isomerization Using High-Resolution Photoelectron Spectroscopy.

Journal of the American Chemical Society·2026

Innovative Method for Evaluating the Optical Properties of Liquid-Liquid Phase Separations Using Laser Scanning Microscopic Spectroscopy.

Microscopy research and technique·2026

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Revisiting the "Art of the Chemical Probe"

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Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control.

Malaria Public Health Status: Global Context and Update on Gulf Cooperation Council Countries.

Emergence of specific binding and catalysis from a designed generalist binding protein.

An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome.

Survey of the human proteostasis network: the ubiquitin-proteasome system.

High-Throughput Platform for Discovery of Chemical Inhibitors of Heat Shock Protein 70 (Hsp70): Adaptation for the Specialized Bacterial HscA-HscB-IscU Complex.

Exploring the Substrate Selectivity of the Condensation Domain VibH through Engineered Adenylation Domains, Non-Native Amide Synthesis, and Substrate Recognition Analysis.

Exploiting Acquired Drug Resistance in Pancreatic Cancer through Selective Covalent Targeting of MAP2K4/7.

From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main Protease.

A Chemigenetic Ca2+ Indicator Based on a Red Fluorescent Protein and a Synthetic Chelator.

Effective Tumor Protection by a Tumor-Associated Mucin-1 Glycopeptide-Based Conjugate Vaccine in a Spontaneous Mouse Breast Cancer Model.

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds an Fe-S Cluster.

Association of rs10741657 polymorphism in CYP2R1 gene with apparently healthy vitamin-D deficient Pakistani subjects.

Percutaneous endoscopic lumbar discectomy combined with annular suture versus PELD alone for single-level lumbar disc herniation: A prospective propensity score-matched cohort study.

Impact of spasmolytic cocktail and Glidesheath Slender on radial artery spasm in transradial cerebral angiography: A randomized factorial trial.

Frustrated Interfacial Solvation Enhances Reaction Rates at Acidified Ice Grain Boundaries in Frozen Microdroplets.

Probing the Quantum Nature of Intramolecular Vibrational Energy Redistribution in HCCH-H2CC Isomerization Using High-Resolution Photoelectron Spectroscopy.

Innovative Method for Evaluating the Optical Properties of Liquid-Liquid Phase Separations Using Laser Scanning Microscopic Spectroscopy.

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Revisiting the "Art of the Chemical Probe"

Related Concept Videos

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