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Related Concept Videos

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Related Experiment Video

Updated: Feb 10, 2026

Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children – Working Memory (CABC-WM)
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Scleroderma in children.

Francesco Zulian1

  • 1Division of Pediatric Rheumatology, Department of Woman and Child Health, University of Padua, Padua, Italy.

Best Practice & Research. Clinical Rheumatology
|May 19, 2018
PubMed
Summary
This summary is machine-generated.

Juvenile scleroderma, a common childhood rheumatic disease, sees advancements in classification and monitoring. New tools like the J4S score and improved assessment systems aid in managing juvenile localized scleroderma and systemic sclerosis.

Keywords:
AssessmentClassificationJuvenile localized sclerodermaJuvenile systemic sclerosisMonitoringOutcomeOutcome measuresSeverity scoreTreatment

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Area of Science:

  • Pediatric Rheumatology
  • Dermatology
  • Immunology

Background:

  • Juvenile scleroderma is the third most common rheumatic disease in children.
  • Recent advancements focus on classification and monitoring for juvenile systemic sclerosis (SSc) and localized scleroderma.
  • Existing pediatric classification criteria for SSc require enhancement.

Purpose of the Study:

  • To review recent developments in the classification and monitoring of juvenile scleroderma.
  • To discuss improvements in pediatric SSc classification criteria.
  • To highlight advancements in assessing and managing localized scleroderma.

Main Methods:

  • Review of recent literature and clinical practice guidelines.
  • Analysis of new classification criteria for adult SSc and their adaptation for pediatric use.
  • Evaluation of multidimensional severity scores like J4S for juvenile SSc.
  • Assessment of scoring systems for localized scleroderma.
  • Consideration of multicenter consensus statements and follow-up studies.

Main Results:

  • New classification criteria for adult SSc are influencing pediatric criteria development.
  • The J4S multidimensional severity score aids in daily patient management for juvenile SSc.
  • Clinical and instrumental scoring systems have enhanced assessment and monitoring of localized scleroderma.
  • Methotrexate is confirmed as a key treatment for localized scleroderma based on consensus and follow-up data.

Conclusions:

  • Ongoing research is refining the classification and monitoring of juvenile scleroderma.
  • The J4S score and improved assessment tools enhance clinical decision-making.
  • Evidence supports the continued use of methotrexate in treating localized scleroderma.