[Corneal endothelial cell therapy, a review].

Area of Science:

• Ophthalmology and Regenerative Medicine
• Corneal cell biology and transplantation alternatives

Background:

• Endothelial dysfunction accounts for about 50% of corneal transplants in France.
• Current endothelial keratoplasty faces challenges including technical difficulty, graft scarcity, and risk of failure or rejection.

Purpose of the Study:

• To review the latest research on corneal endothelial cell therapy as a novel treatment.
• To explore cell therapy as a less invasive and more effective alternative to corneal grafting.

Main Methods:

• Literature review focusing on advancements in corneal endothelial cell therapy.
• Analysis of the potential of stem cell engineering adapted for corneal endothelial cells.

Main Results:

• The human cornea's avascular and immunologically privileged nature makes it suitable for cell transplantation.
• Progress in corneal epithelial stem cell therapy inspires adaptation for endothelial cell treatments.

Conclusions:

• Corneal endothelial cell therapy presents a viable strategy to address limitations of current corneal transplantation.
• Further research in this area holds significant promise for treating corneal endothelial dysfunction.