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Related Experiment Videos

Ninety-eight fixed drug eruptions with provocation tests.

A J Kanwar1, S C Bharija, M Singh

  • 1Department of Medicine, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya.

Dermatologica
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Fixed drug eruptions were studied in 98 patients using provocation tests. Trimethoprim-sulphamethoxazole and acetylsalicylic acid were the most common culprits, with some cross-sensitivity observed between oxyphenbutazone and phenylbutazone.

Area of Science:

  • Dermatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Fixed drug eruptions (FDE) are a type of adverse drug reaction.
  • Understanding causative agents and patterns of FDE is crucial for patient management.

Purpose of the Study:

  • To identify the drugs most frequently implicated in fixed drug eruptions.
  • To investigate the clinical presentation and patterns of FDE.
  • To assess potential cross-sensitivity between drugs.

Main Methods:

  • Ninety-eight patients diagnosed with fixed drug eruptions were enrolled.
  • Provocation tests were performed to identify the causative agents.
  • Clinical involvement (cutaneous, mucosal, or both) was recorded.

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Main Results:

  • Trimethoprim-sulphamethoxazole (45 patients) and acetylsalicylic acid (24 patients) were the most common causative drugs.
  • Cutaneous involvement occurred in 43 patients, mucous membrane in 33, and both in 22.
  • Cross-sensitivity was noted between oxyphenbutazone and phenylbutazone.

Conclusions:

  • Trimethoprim-sulphamethoxazole and acetylsalicylic acid are significant causes of fixed drug eruptions.
  • FDE can manifest with cutaneous, mucosal, or combined involvement.
  • Awareness of drug cross-sensitivity is important for preventing recurrent reactions.