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Updated: Feb 10, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
MiR-199a-3p acts as a tumor suppressor in clear cell renal cell carcinoma
Jianmin Liu1, Beibei Liu1, Yuanyuan Guo1
1Department of Urology, First Affiliated Hospital of Bengbu Medical College, Anhui Province, PR China.
Objectives:
To explore the biological function and mechanism of miR-199a-3p in clear cell renal cell carcinoma (CCRCC).
Methods:
We investigated the expression of miR-199a-3p in CCRCC through quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Over expression of miR-199a-3p was performed in CCRCC cell lines, and cell growth curve, colony formation capacity, cell invasion, wound healing and cell apoptosis assay were used for investigating the roles of miR-199a-3p in CCRCC.
Results:
The expression of miR-199a-3p in CCRCC tissues was significantly lower than that in para-carcinoma tissues. Functional assay showed that over expression of miR-199a-3p influenced cell growth, colony formation, cell invasion, cell migration and cell apoptosis in CCRCC cell lines.
Conclusions:
Our work suggested that miR-199a-3p was related to cell growth, colony formation, cell invasion, cell migration and cell apoptosis, which might act as a tumor suppressor in CCRCC.
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