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Updated: Feb 10, 2026

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Retinopathy and Mortality.

Emily Frith1,2, Paul D Loprinzi1,2,3

  • 1Physical Activity Epidemiology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, Oxford, MS.

Diabetes Spectrum : a Publication of the American Diabetes Association
|May 19, 2018
PubMed
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Retinopathy, a condition affecting the eyes, is linked to a higher risk of death from any cause in U.S. adults. Even mild cases of retinopathy increase all-cause mortality risk.

Area of Science:

  • Ophthalmology
  • Public Health
  • Epidemiology

Background:

  • Diabetic retinopathy is a leading cause of vision loss.
  • The association between retinopathy and overall mortality requires further investigation in diverse populations.

Purpose of the Study:

  • To assess the relationship between retinopathy and all-cause mortality in a U.S. adult population.
  • To determine if different severities of retinopathy correlate with varying mortality risks.

Main Methods:

  • Utilized data from 4,777 adults in the 2005-2008 National Health and Nutrition Examination Survey.
  • Screened for nonproliferative retinopathy using established grading criteria and objective retinal imaging.
  • Excluded participants with pre-existing cardiovascular conditions like heart attack or stroke.

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Main Results:

  • Both mild and moderate/severe retinopathy were significantly associated with increased all-cause mortality.
  • Adjusted models showed an 81% increased risk for mild retinopathy and a 314% increased risk for moderate/severe retinopathy compared to no retinopathy.

Conclusions:

  • Mild or moderate/severe retinopathy indicates an elevated risk of all-cause mortality in U.S. adults.
  • Retinopathy serves as a potential indicator for increased mortality risk.