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Distribution of virulence-associated genes and antimicrobial susceptibility in clinical Acinetobacter baumannii

Chao Liu1, Yaowen Chang1, Ying Xu2

  • 1Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, Sichuan, China.

Oncotarget
|May 19, 2018
PubMed

Insights

Multidrug-resistant Acinetobacter baumannii, a significant hospital pathogen, shows high prevalence of virulence genes in epidemic strains. These findings highlight the challenge in treating these infections.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Molecular Epidemiology

Background:

  • Acinetobacter baumannii is a critical pathogen causing hospital-acquired infections.
  • Multidrug resistance and virulence are key factors in its pathogenicity.
  • The molecular epidemiology of virulence in A. baumannii is less understood than its drug resistance.

Purpose of the Study:

  • To investigate the characteristics of virulence-associated genes in multidrug-resistant (MDR) and non-MDR Acinetobacter baumannii clinical isolates.
  • To analyze the distribution of selected virulence genes in relation to antimicrobial resistance patterns.

Main Methods:

  • Collected 88 Acinetobacter baumannii clinical isolates.
  • Performed antimicrobial susceptibility testing against 10 common antibiotics.
  • Analyzed the distribution of 9 selected virulence-associated genes.
  • Utilized Pulsed Field Gel Electrophoresis (PFGE) to differentiate epidemic and sporadic isolates.

Main Results:

  • High resistance rates (>50%) were observed for ciprofloxacin, gentamicin, amikacin, tobramycin, doxycycline, meropenem, and imipenem.
  • Multidrug-resistant isolates predominated in the epidemic group (79.5%) compared to the sporadic group (6.7%).
  • High proportions of virulence genes (e.g., bap, surA1, BasD) were found, particularly in MDR epidemic isolates.

Conclusions:

  • MDR Acinetobacter baumannii isolates, especially epidemic strains, possess a high prevalence of virulence genes.
  • The co-occurrence of multidrug resistance and virulence factors in epidemic isolates poses a significant clinical challenge.
  • Further research is needed to understand the interplay between virulence and resistance in A. baumannii pathogenesis.
Keywords:
Acinetobacter baumanniiMDRPFGEantimicrobial resistancevirulence genes

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