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Development of a cost-effective production process for Halomonas levan
Burak Adnan Erkorkmaz1, Onur Kırtel1, Özlem Ateş Duru2
1IBSB-Industrial Biotechnology and Systems Biology Research Group, Department of Bioengineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.
Bioprocess and Biosystems Engineering
|May 19, 2018
Summary
This study optimized non-sterile levan polysaccharide production using halophilic Halomonas smyrnensis. Cost-effective methods achieved record yields and efficiency for this valuable natural polymer.
Area of Science:
- Biotechnology
- Microbial Production
- Natural Polymers
Background:
- Levan polysaccharide is a valuable natural polymer with industrial applications.
- Current production methods face economic and scalability challenges.
- Halophilic bacteria, specifically Halomonas smyrnensis, offer potential for improved levan production.
Purpose of the Study:
- To optimize non-sterile levan production using Halomonas smyrnensis.
- To identify cost-effective raw materials for levan synthesis.
- To enhance levan yield and bioconversion efficiency.
Main Methods:
- Screening of low-cost sucrose, salt, and boron sources.
- Optimization of pH control and bioreactor conditions (batch and fed-batch).
- Evaluation of non-sterile production conditions.
Main Results:
- Identified optimal low-cost substitutes for sucrose, salt, and boron.
- Achieved the highest reported levan yield (18.06 g/L) for this microbial system.
- Demonstrated the highest theoretical bioconversion efficiency for levan-producing suspension cultures.
Conclusions:
- Developed a cost-effective, non-sterile process for levan polysaccharide production.
- Utilized halophilicity advantage of Halomonas smyrnensis for efficient levan synthesis.
- Verified the structural integrity and biocompatibility of the produced levan.
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