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Obstructive Sleep Apnea and Testosterone Deficiency.

Sung Dong Kim1, Kyu Sup Cho2

  • 1Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

The World Journal of Men'S Health
|May 19, 2018
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) is linked to low testosterone in men. Testosterone replacement therapy (TRT) may help sexual dysfunction but can worsen OSA, especially in severe cases.

Keywords:
Continuous positive airway pressureErectile dysfunctionSexual dysfunction, physiologicalSleep apnea, obstructiveTestosterone

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Area of Science:

  • Endocrinology
  • Sleep Medicine
  • Men's Health

Background:

  • Obstructive sleep apnea (OSA) is a prevalent condition causing intermittent hypoxia and sleep disruption.
  • OSA in middle-aged men frequently correlates with diminished testosterone secretion, obesity, and aging.
  • The interplay between OSA, testosterone levels, and associated health issues requires further investigation.

Purpose of the Study:

  • To examine the relationship between OSA and testosterone secretion in men.
  • To evaluate the efficacy and safety of testosterone replacement therapy (TRT) in men with OSA.
  • To provide guidance on the use of TRT in patients with OSA, considering potential risks and benefits.

Main Methods:

  • Review of existing literature on OSA, hypogonadism, and TRT.
  • Analysis of studies investigating testosterone levels in men with OSA.
  • Assessment of clinical outcomes and adverse events in patients undergoing TRT for OSA-related hypogonadism.

Main Results:

  • OSA is commonly associated with decreased testosterone levels in middle-aged men.
  • While OSA treatment alone may not consistently restore testosterone, TRT can improve hypogonadism and sexual dysfunction.
  • TRT may exacerbate OSA in some individuals, particularly those with severe, untreated OSA.

Conclusions:

  • TRT can be beneficial for hypogonadism and sexual dysfunction in men with OSA.
  • Careful monitoring for OSA symptoms is crucial before and after initiating TRT.
  • TRT should be used cautiously or avoided in patients with severe untreated OSA due to potential exacerbation of the condition.