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Microhoneycomb Monoliths Prepared by the Unidirectional Freeze-drying of Cellulose Nanofiber Based Sols: Method and Extensions
Published on: May 24, 2018
Zn2+-loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in
Huibin Yu1,2, Hongqin Ke3, Tu Chen4
1a College of Life Science and Technology , Huazhong University of Science and Technology , Wuhan , China.
Abstract:
Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn2+ loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn2+-loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn2+ concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying. The results may be caused by porosity of the adsorbent enlarged via freeze-drying and improved stability by coating with chitosan. In addition, the adsorbent shows better selectivity and storage stability and could be a potential adsorbent to treat prostate cancer.
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