Related Experiment Video

Updated: Feb 10, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.7K

Human Endophthalmitis Caused By Pseudorabies Virus Infection, China, 2017

Jing-Wen Ai, Shan-Shan Weng, Qi Cheng

    Emerging Infectious Diseases
    |May 19, 2018
    PubMed

    Insights

    Pseudorabies virus can cause human endophthalmitis after sewage exposure on hog farms. This rare infection highlights potential zoonotic risks from contaminated environments.

    Area of Science:

    • Ophthalmology
    • Virology
    • Zoonotic Diseases

    Background:

    • Pseudorabies virus (PRV) is a herpesvirus primarily affecting swine.
    • Human infections with PRV are exceptionally rare.
    • Endophthalmitis is a severe inflammation of the eye's interior.

    Observation:

    • A case of human endophthalmitis occurred in China.
    • The patient had recent exposure to sewage on a hog farm.
    • Vitreous humor samples were collected for analysis.

    Findings:

    • High-throughput sequencing and real-time PCR confirmed PRV in the patient's vitreous humor.
    • This is the first reported case of human endophthalmitis caused by PRV.
    • The findings suggest direct contact with contaminated materials as a transmission route.

    Implications:

    • PRV should be considered in the differential diagnosis of endophthalmitis in individuals with relevant exposure history.
    • This case underscores the potential for zoonotic transmission of PRV to humans.
    • Enhanced biosecurity measures on farms may be necessary to prevent human exposure to swine viruses.
    Keywords:
    AlphaherpesvirinaeChinaHerpesviridaeHuman endophthalmitisJiangxi ProvinceSuid herpesvirus 1endophthalmitishigh-throughput nucleotide sequencinghog farmpseudorabiesswineherderviruses

    More Related Videos

    An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

    An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

    Published on: December 10, 2013

    8.4K
    Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster09:57

    Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster

    Published on: March 14, 2019

    11.4K

    Related Concept Videos

    What are Viruses?00:50

    What are Viruses?

    Overview
    128.4K
    Infection01:20

    Infection

    When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
    The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
    12.8K
    Introduction to Virus01:28

    Introduction to Virus

    Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
    1.8K
    Viruses of Archaea01:29

    Viruses of Archaea

    Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
    525
    Viruses with RNA Genomes01:29

    Viruses with RNA Genomes

    RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
    948
    Stages of Infection01:26

    Stages of Infection

    Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
    65.5K