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Use of Bead-Based Serologic Assay to Evaluate Chikungunya Virus Epidemic, Haiti

Eric W Rogier, Delynn M Moss, Kimberly E Mace

    Emerging Infectious Diseases
    |May 19, 2018
    PubMed

    The index case of chikungunya virus (CHIKV) in Haiti was reported during early 2014; the vector, the pervasive Aedes aegypti mosquito, promoted rapid spread throughout the country. During December 2014-February 2015, we collected blood samples from 4,438 persons at 154 sites (62 urban, 92 rural) throughout Haiti and measured CHIKV IgG by using a multiplex bead assay. Overall CHIKV seroprevalence was 57.9%; differences between rural (mean 44.9%) and urban (mean 78.4%) areas were pronounced. Logistic modeling identified the urban environment as a strong predictor of CHIKV exposure (adjusted odds ratio 3.34, 95% CI 2.38-4.69), and geographic elevation provided a strong negative correlation. We observed no correlation between age and antibody positivity or titer. Our findings demonstrated through serologic testing the recent and rapid dissemination of the arbovirus throughout the country. These results show the utility of serologic data to conduct epidemiologic studies of quickly spreading mosquitoborne arboviruses.

    Keywords:
    Aedes aegyptiAlbopictusCHIKVHaitiarboviruschikungunyaimmunoassaymosquitoesserologyvector-borne infectionsviruses

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