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Updated: Feb 10, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Recent Changes of Classification for Squamous Intraepithelial Lesions of the Head and Neck
1From the Department of Pathology, University of Ulsan College Medicine, Asan Medical Center, Seoul, Korea.
Context:
- Interpretation of atypical squamous lesions of the head and neck has always been a nettlesome task for pathologists. Moreover, many different grading systems for squamous intraepithelial lesions have been proposed in past decades. The recent World Health Organization 2017 classification presents 2 types of 2-tier systems for laryngeal and oral precursor lesions.
Objective:
- To review the recent changes in classification and the clinical significance for squamous intraepithelial lesions of the head and neck.
Data Sources:
- Personal experience and data from the literature.
Conclusions:
- The 2-tier grading system for laryngeal dysplasia, presented by World Health Organization in 2017, is expected to improve diagnostic reproducibility and clinical implication. However, the diagnostic criteria for low-grade dysplasia do not distinguish it clearly from basal cell hyperplasia. The World Health Organization 2017 classification of oral epithelial dysplasia remains unclear, and complicated and variable grading systems still make head and neck intraepithelial lesions difficult to interpret.
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