Related Experiment Videos
Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity
C S Taft1, T Stark, C P Selitrennikoff
1Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262.
Antimicrobial Agents and Chemotherapy
|December 1, 1988
Abstract:
Cilofungin (LY121019) inhibited Candida albicans growth and activity of (1-3)-beta-glucan synthase, for which it was a noncompetitive inhibitor with a Ki-app of 2.5 microM. Cilofungin had no effect on chitin synthase activity. Based on these and other data, it seems likely that cilofungin inhibits fungal growth by inhibiting (1-3)-beta-glucan synthase activity.