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The Mouse Heart Attack Research Tool 1.0 database.

Kristine Y DeLeon-Pennell1,2, Rugmani Padmanabhan Iyer1, Yonggang Ma1

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The Mouse Heart Attack Research Tool (mHART) is a large database of over 888,000 cardiovascular data points from 2,100 mice. It aids researchers in discovering new markers for left ventricular remodeling after heart attack in mice.

Keywords:
big databioinformaticscardiovascular diseasemyocardial infarctionproteomics

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Area of Science:

  • Cardiovascular Research
  • Big Data in Biology
  • Systems Biology

Background:

  • Big data enables systems-level understanding of cardiovascular pathology.
  • Integrating diverse data (genetic, proteomic, pathophysiological) drives discovery.
  • The Mouse Heart Attack Research Tool (mHART) consolidates extensive experimental data.

Purpose of the Study:

  • To establish a comprehensive database (mHART) for cardiovascular research.
  • To facilitate hypothesis generation and identification of predictive markers for left ventricular remodeling post-myocardial infarction (MI) in mice.
  • To provide a standardized framework for data integration in cardiovascular research.

Main Methods:

  • Designed and populated the mHART REDCap database with over 10 years of experimental data.
  • Collected physiological, biochemical, cellular, and proteomic data from male and female mice (3-36 months old) post-MI and control groups.
  • Implemented rigorous data quality assessment and curation processes.

Main Results:

  • mHART 1.0 contains over 888,000 data points from more than 2,100 unique mice.
  • The database integrates multi-platform data, including genomic, proteomic, histological, and physiological outputs.
  • Database utility was demonstrated with performance testing and illustrative examples.

Conclusions:

  • mHART provides a valuable resource for cardiovascular research, consolidating a large, multi-platform dataset.
  • The database supports the identification of novel hypotheses and predictive biomarkers for adverse left ventricular remodeling after MI.
  • mHART serves as a model for developing similar integrated databases in biomedical research.