Related Experiment Video
Updated: Feb 10, 2026

Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
The Quest for Stability during Times of Change
1Cell Systems, Cell Press, 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA.
Abstract:
Experimental tools that are designed to perturb biological functions are often used to understand how cells change over time. However, in two recent papers, Segall-Shapiro et al. (2018; in Nature Biotechnology) and Rullan et al. (2018; in this issue of Molecular Cell) present tools engineered to keep cells the same. Both tools achieve perfect adaptation, that is, the ability to hold a value, in this case gene expression, constant over time despite disruptions and disturbances. Together, these papers highlight how influential dynamics can be when shaping biological functions, even when the goal is to stay constant.
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