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Defining the osteoarthritis patient: back to the future
G P Dobson1, H L Letson1, A Grant2
1Heart, Trauma and Sepsis Research Laboratory, College of Medicine and Dentistry, 1 James Cook Drive, James Cook University, Queensland, 4811, Australia.
Osteoarthritis and Cartilage
|May 19, 2018
Summary
The history of osteoarthritis (OA) reveals evolving concepts from
Area of Science:
- Rheumatology and Medical History
- Understanding Osteoarthritis (OA) Pathogenesis
Background:
- The nomenclature and conceptualization of osteoarthritis (OA) have evolved significantly since the mid-nineteenth century.
- Early debates distinguished OA from other arthritic conditions and explored its underlying mechanisms, including 'wear-and-tear' versus whole-joint disease theories.
Observation:
- Historical perspectives highlight the early recognition of inflammation and neurogenic factors in OA.
- The 20th century saw major advancements in diagnostics, treatments, and surgical interventions for OA.
- Contemporary understanding defines OA as a multi-disease involving inflammation, immune, and central nervous system (CNS) dysfunction.
Findings:
- Osteoarthritis (OA) is now understood as a complex, multi-faceted disease.
- Inflammation, immune responses, and CNS dysfunction are recognized as key contributors to OA pathology, pain, and disability.
- Despite advancements, the complete understanding and cure for OA remain elusive.
Implications:
- Historical insights provide a crucial foundation for current OA research and clinical practice.
- The ongoing 'omics' era promises deeper insights into OA's complexities.
- Further research is essential to develop effective treatments and ultimately find a cure for osteoarthritis.
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