Related Experiment Video

Updated: Feb 10, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.7K

A novel oncogene URG4/URGCP and its role in cancer

Yavuz Dodurga1, Mücahit Seçme1, N Lale Şatıroğlu-Tufan2

  • 1Pamukkale University Medical Faculty Department of Medical Biology, Denizli, Turkey.

Gene
|May 19, 2018
PubMed

Insights

A novel gene, Upregulator of cell proliferation (URG4/URGCP), induced by hepatitis-B virus X antigen, shows potential as an oncogene. Its expression correlates with various cancers, suggesting a role in carcinogenesis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Oncogenes are mutated proto-oncogenes driving cancer development.
  • New genes with oncogenic or tumor-suppressing potential are continually being identified.
  • The novel Upregulator of cell proliferation (URG4/URGCP) gene, induced by hepatitis-B virus X antigen (HBxAg), has recently been discovered.

Purpose of the Study:

  • To investigate the oncogenic potential of the URG4/URGCP gene.
  • To explore the relationship between URG4/URGCP expression and clinicopathological characteristics in various cancers.

Main Methods:

  • Identification and registration of the URG4/URGCP gene in NCBI-GenBank.
  • Localization of URG4/URGCP on chromosome 7p13.
  • Evaluation of URG4/URGCP expression in relation to clinicopathological features across different cancer types.

Main Results:

  • URG4/URGCP is located on chromosome 7p13 and encodes a 922-amino acid protein.
  • Significant correlations between URG4/URGCP expression and clinicopathological characteristics were observed in hepatocellular carcinoma, osteosarcoma, nasopharyngeal carcinoma, bladder cancer, gastric cancer, and glioma.
  • The precise biological activity and mechanism of URG4/URGCP in malignant cells require further elucidation.

Conclusions:

  • URG4/URGCP is a putative oncogene implicated in multistep carcinogenesis.
  • The gene plays a role in cell cycle regulation and other critical cellular processes.
  • URG4/URGCP represents a promising target for cancer research and potential therapeutic strategies.
Keywords:
CancerOncogeneURG4/URGCP

More Related Videos

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.6K

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.5K
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Role of Culture01:23

The Role of Culture

Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
438
Role-Based Identity01:21

Role-Based Identity

Role-based identities are central to understanding how individuals navigate social environments by adopting distinct self-conceptions aligned with various societal roles. These identities are not fixed traits but are constructed through personal actions and the social feedback individuals receive in context-specific interactions. Each social role, such as student, teacher, or friend, carries a set of expectations and norms that influence how people think, feel, and behave within that...
220
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.6K
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.3K