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Related Experiment Video

Updated: Feb 10, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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PKM2, a potential target for regulating cancer.

Yu-Huan Li1, Xiao-Feng Li2, Jia-Tao Liu1

  • 1Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China.

Gene
|May 19, 2018
PubMed
Summary

Pyruvate kinase M2 (PKM2) drives cancer growth by altering glucose metabolism and regulating genes for proliferation. Targeting PKM2 offers potential for cancer diagnosis and treatment.

Keywords:
CancerMetabolismPyruvate kinase M2

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Cancer cells exhibit aberrant glucose metabolism, preferentially using glycolysis even with oxygen.
  • Pyruvate kinase (PK) is a key enzyme in glucose metabolism, with PKM2 being prevalent in proliferating cells like cancer cells.

Purpose of the Study:

  • To review recent advances in understanding the regulation and function of PKM2 in tumorigenesis.
  • To explore PKM2's role in cancer progression via metabolic and non-metabolic pathways.

Main Methods:

  • Literature review of recent research on PKM2 in cancer.
  • Analysis of PKM2's involvement in glycolysis and gene expression regulation.

Main Results:

  • PKM2 facilitates cancer cell proliferation by providing essential metabolic intermediates.
  • PKM2 influences tumor growth by regulating genes involved in cell proliferation, migration, and apoptosis.

Conclusions:

  • PKM2 plays a critical role in cancer progression through diverse mechanisms.
  • PKM2 represents a potential therapeutic target for cancer diagnosis and treatment.