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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Dysregulated Network of miRNAs Involved in the Pathogenesis of Multiple Sclerosis
Sanam Dolati1, Faroogh Marofi2, Zohreh Babaloo3
1Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
Multiple sclerosis (MS) is a chronic and organ-specific autoimmune disease in which immune cells act against the myelin sheath, resulting in central nervous system (CNS) damage. It has been revealed that miRNAs can play significant role in the pathogenesis of MS. These regulatory molecules lead to the activation of different signaling pathways, regulation of several transcriptional factors, influencing the differentiation of Th17 cells, development of Tregs and alteration from Th2 to Th1 response in MS. New studies have discovered that dysregulation of miRNAs may trigger abnormal immune responses leading consequently in the emergence of autoimmunity. In this review, we have discussed the altered expression patterns of miRNAs discovered in MS patients. These types of dysregulated miRNAs have been associated with MS pathogenesis. Current outcomes propose that such dysregulated miRNAs are potential to serve as useful biomarkers to diagnose MS, and to recognize new healing targets for its treatment.
Insights
MicroRNAs (miRNAs) play a key role in multiple sclerosis (MS) pathogenesis by regulating immune responses. Dysregulated miRNAs in MS patients offer potential as diagnostic biomarkers and therapeutic targets.
Area of Science:
- Neuroimmunology
- Molecular Biology
- Autoimmune Diseases
Background:
- Multiple sclerosis (MS) is a chronic autoimmune disease targeting the central nervous system (CNS).
- Immune cell-mediated attack on myelin sheath causes CNS damage in MS.
- MicroRNAs (miRNAs) are implicated in the pathogenesis of MS, influencing immune cell differentiation and responses.
Purpose of the Study:
- To review the altered expression patterns of miRNAs in multiple sclerosis (MS) patients.
- To explore the association between dysregulated miRNAs and MS pathogenesis.
- To identify potential diagnostic biomarkers and therapeutic targets for MS based on miRNA alterations.
Main Methods:
- Review of current literature on miRNA expression in MS patients.
- Analysis of studies investigating the role of miRNAs in immune pathways relevant to MS.
- Synthesis of findings on miRNA dysregulation and its link to MS development.
Main Results:
- Altered expression patterns of specific miRNAs have been identified in MS patients.
- Dysregulated miRNAs are associated with key pathological processes in MS, including immune cell differentiation and response.
- These miRNAs influence signaling pathways and transcriptional factors involved in MS.
Conclusions:
- Dysregulated miRNAs are significantly associated with the pathogenesis of multiple sclerosis (MS).
- Altered miRNA expression in MS patients presents a potential avenue for developing diagnostic biomarkers.
- Targeting dysregulated miRNAs may offer novel therapeutic strategies for MS treatment.
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