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Non-invasive Assessment of Microvascular and Endothelial Function
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[Correlation of functional and structural changes of the cardiovascular system in hypertensive disease]

Ia V Skards, A V Vitols, D R Matisone

    Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova
    |November 1, 1988
    PubMed

    Insights

    Effective antihypertensive treatment reduces left ventricular mass and myocardial hypertrophy. However, forearm arterial resistance remains high due to increased smooth muscle activity, indicating persistent vascular changes in hypertension.

    Area of Science:

    • Cardiovascular medicine
    • Hypertension research
    • Vascular physiology

    Background:

    • Hypertension leads to cardiac and vascular structural changes.
    • Understanding the dynamics of these changes during treatment is crucial.

    Purpose of the Study:

    • To investigate the effects of antihypertensive treatment on left ventricular mass, forearm arterial resistance, and venous compliance.
    • To explore the relationship between pressure reduction, myocardial hypertrophy regression, and vascular remodeling.

    Main Methods:

    • Longitudinal study of hypertensive patients over 3 years.
    • Monitoring left ventricular mass, forearm arterial minimal resistance, and forearm venous compliance.
    • Assessing changes in relation to effective antihypertensive therapy.

    Main Results:

    • Significant reduction in left ventricular mass and myocardial hypertrophy observed.
    • Forearm arterial minimal resistance remained elevated despite treatment.
    • Increased contractile activity of vascular smooth muscles contributes to persistent elevated resistance.

    Conclusions:

    • Antihypertensive treatment effectively reduces cardiac hypertrophy.
    • Vascular structural changes, indicated by persistent elevated resistance, may require further therapeutic strategies.
    • Accurate assessment of structural changes necessitates standardized transmural pressure measurements.

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