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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Epigenetic-based companion diagnostics.

Leander Van Neste1, Gregory R Jones2, Wim Van Criekinge1

  • 1MDxHealth PharmacoDx, Technologiepark 4, 9052 Ghent, Belgium.

Personalized Medicine
|May 20, 2018
PubMed
Summary
This summary is machine-generated.

DNA methylation, a key epigenetic marker, shows potential as a companion diagnostic for cancer. This approach could personalize treatment, avoiding both undertreatment and overtreatment side effects.

Keywords:
DNA methylationMBD2 affinityMGMTMSPcompanion diagnosticepigenetics

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Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Diagnostics

Background:

  • Current cancer treatment relies on standard protocols, often leading to undertreatment or overtreatment due to lack of personalized information.
  • Patients may experience delays in effective treatment or unnecessary side effects from toxic chemotherapy.
  • Epigenetic markers, particularly DNA methylation, are crucial regulators of gene expression and play a significant role in cancer development and progression.

Purpose of the Study:

  • To assess the potential of DNA methylation as a companion diagnostic tool in oncology.
  • To explore development pathways for DNA methylation-based companion diagnostics.
  • To highlight how biomarker development, biological pathways, and clinical utility converge in epigenetic diagnostics.

Main Methods:

  • Review of epigenetic markers, focusing on DNA methylation in cancer.
  • Exploration of development pathways for companion diagnostics.
  • Case study analysis of MGMT (O6-methylguanine-DNA methyltransferase) epigenetic silencing.

Main Results:

  • DNA methylation is a frequent, stable, and abundant cancer mark implicated in oncogenesis.
  • Epigenetic silencing of MGMT serves as a prime example of a successful epigenetic companion diagnostic.
  • Development pathways illustrate the integration of biological insights and clinical application.

Conclusions:

  • DNA methylation holds significant promise as a companion diagnostic for personalized cancer therapy.
  • Epigenetic companion diagnostics can improve treatment efficacy and reduce patient exposure to unnecessary toxicity.
  • The MGMT example demonstrates the successful translation of epigenetic biomarker research into clinical utility.