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Updated: Feb 10, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Neutrophils in traumatic brain injury (TBI): friend or foe?
Yang-Wuyue Liu1,2, Song Li2, Shuang-Shuang Dai3,4
1Department of Biochemistry and Molecular Biology, Army Medical University, Chongqing, 400038, People's Republic of China.
Abstract:
Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI.
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