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Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens
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Tracing Environmental Exposure from Neurodevelopment to Neurodegeneration
Amy L Heffernan1, Dominic J Hare2
1Melbourne Dementia Research Centre at The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Parkville, VIC, Australia.
Trends in Neurosciences
|May 20, 2018
Summary
Genetic and environmental factors influence brain development and neurodegeneration. The
Area of Science:
- Neuroscience
- Environmental Health
- Genetics
Background:
- Genetic and environmental factors interact throughout critical developmental periods.
- These interactions impact neurodevelopment and neurodegeneration.
- Understanding these influences is crucial for brain health.
Purpose of the Study:
- Introduce the 'neuroexposome' concept.
- Highlight the brain's unique response to environmental exposures.
- Explore the role of 'omics' sciences in understanding brain health and disease.
Main Methods:
- Conceptual framework development.
- Literature review on genetic-environmental interactions.
- Integration of 'omics' data in neuroscience.
Main Results:
- The 'neuroexposome' framework provides a novel perspective on brain-environment interactions.
- 'Omics' technologies offer powerful tools to study these interactions.
- This approach can elucidate disease pathogenesis.
Conclusions:
- The 'neuroexposome' concept is vital for understanding brain health and disease.
- Integrating 'omics' data with environmental exposure information is key.
- This research can inform future public health policies for neuroprotection.
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