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The value of peripheral perfusion index measurements for early detection of critical cardiac defects

Ozgun Uygur1, Ozge Altun Koroglu1, Erturk Levent2

  • 1Ege University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Izmir, Turkey.

Pediatrics and Neonatology
|May 20, 2018
PubMed

Insights

Peripheral perfusion index (PPI) measurements enhance screening for critical congenital heart disease (CCHD). Adding PPI to pulse oximetry improved detection, especially for obstructive left heart lesions.

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Medical Diagnostics

Background:

  • Critical congenital heart disease (CCHD) affects approximately 25% of newborns and requires timely intervention.
  • Early detection of CCHD is crucial for improving infant outcomes.
  • Pulse oximetry is a standard screening tool, but limitations exist.

Purpose of the Study:

  • To evaluate the added value of peripheral perfusion index (PPI) measurements to pulse oximetry screening for CCHD.
  • To assess the efficacy of combined screening methods in detecting CCHD.
  • To identify specific CCHD subtypes where PPI may offer diagnostic advantages.

Main Methods:

  • Prospective study including 3175 newborns between May 2013 and September 2015.
  • Measurements included physical examination, pre- and postductal oxygen saturation, and PPI using a new generation pulse oximeter.
  • Data collected before hospital discharge.

Main Results:

  • All 33 newborns with antenatal CCHD diagnosis were detected.
  • Three additional infants with CCHD were identified through combined screening, despite negative pulse oximetry.
  • The combination of physical examination, pulse oximetry, and PPI successfully detected all CCHD cases.

Conclusions:

  • Peripheral perfusion index (PPI) measurements can significantly enhance the early detection of critical congenital heart disease (CCHD).
  • The addition of PPI to pulse oximetry screening improves diagnostic accuracy, particularly for obstructive left heart lesions.
  • Combined screening methods offer a more comprehensive approach to identifying CCHD in newborns.
Abstract

Keywords:
congenital heart diseaseperfusion indexpulse oximetryscreening

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