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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Mycophenolate mofetil-induced colitis in a patient with systemic sclerosis
Gianluca Moroncini1,2, Devis Benfaremo1,2, Alessandra Mandolesi3
1Dipartimento Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.
BMJ Case Reports
|May 20, 2018
Summary
A patient with systemic sclerosis (SSc) developed colitis due to mycophenolate mofetil (MMF). Stopping MMF led to rapid recovery, highlighting a potential side effect in SSc-ILD treatment.
Area of Science:
- Gastroenterology
- Rheumatology
- Pharmacology
Background:
- Systemic sclerosis (SSc) is a complex autoimmune disease.
- Interstitial lung disease (ILD) is a common complication of SSc.
- Mycophenolate mofetil (MMF) is used to treat SSc-related ILD.
Observation:
- A 44-year-old woman with SSc presented with abdominal pain, nausea, vomiting, and fever.
- Imaging revealed a thickened colon wall, and endoscopy showed multiple serpiginous ulcers.
- These symptoms arose during MMF treatment for SSc-ILD.
Findings:
- The patient was diagnosed with drug-induced colitis, suspected to be caused by MMF.
- Discontinuation of MMF resulted in rapid clinical improvement.
- Follow-up colonoscopy confirmed complete resolution of colonic ulcers.
Implications:
- This case is the first reported instance of MMF-induced colitis in a patient with SSc-ILD.
- Clinicians should consider MMF-induced colitis in SSc patients presenting with gastrointestinal symptoms.
- Awareness of this adverse effect is crucial for patient management and treatment adjustments.
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