Related Experiment Video
Updated: Feb 10, 2026

In vivo Visualization of Synaptic Vesicles Within Drosophila Larval Segmental Axons
Published on: October 15, 2010
Bantam regulates the axonal geometry of Drosophila larval brain by modulating actin regulator enabled
Animesh Banerjee1, Jagat Kumar Roy2
1Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India.
Abstract:
During development, axonogenesis, an integral part of neurogenesis, is based on well-concerted events comprising generation, rearrangement, migration, elongation, and adhesion of neurons. Actin, specifically the crosstalk between the guardians of actin polymerization, like enabled, chickadee, capping protein plays an essential role in crafting several events of axonogenesis. Recent evidences reflect multifaceted role of microRNA during axonogenesis. Here, we investigated the role of bantam miRNA, a well-established miRNA in Drosophila, in regulating the actin organization during brain development. Our immunofluorescence studies showed altered arrangement of neurons and actin filaments whereas both qPCR and western blot revealed elevated expression of enabled, one of the actin modulators in bantam mutant background. Collectively, our results clearly demonstrate that bantam plays an instrumental role in shaping the axon architecture regulating the actin geometry through its modulator enabled.
More Related Videos
09:42Morphological Analysis of Drosophila Larval Peripheral Sensory Neuron Dendrites and Axons Using Genetic Mosaics
Published on: November 7, 2011
07:06Author Spotlight: Investigating Asymmetric Cell Division Dynamics: A Protocol for Live-Imaging of Drosophila Larval Brain Explants
Published on: June 23, 2023
Related Concept Videos
Epigenetic Regulation
GTPases and their Regulation
Large G-proteins,...
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Master Transcription Regulators
Negative Regulator Molecules
Positive Regulator Molecules