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Updated: Aug 3, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Mucosal Ablation in Patients with Barrett's Esophagus: Fry or Freeze?
Kavel Visrodia1, Liam Zakko1, Kenneth K Wang2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First Ave., SW, Rochester, MN, 55905, USA.
Abstract:
The management of Barrett's esophagus and early esophageal adenocarcinoma has shifted away from esophagectomy and toward endoscopic techniques, including endoscopic resection and ablative therapies. The most commonly used ablative therapies are radiofrequency ablation and cryotherapy. Radiofrequency ablation has risen to the top of the management algorithm due to its favorable safety profile and established track record of efficacy in patients with dysplastic Barrett's. Cryotherapy offers early promise as an alternatively safe and effective ablative modality. We review radiofrequency ablation and cryotherapy techniques, and updated data regarding their efficacy and safety as well as their roles in the management of Barrett's esophagus.
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