Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vapor Pressure Lowering03:28

Vapor Pressure Lowering

31.4K
The equilibrium vapor pressure of a liquid is the pressure exerted by its gaseous phase when vaporization and condensation are occurring at equal rates:
31.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
Design Consideration01:22

Design Consideration

586
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
586
Sampling Plans01:23

Sampling Plans

999
Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
999
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

4.4K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.4K
Tensile Strength Considerations of Concrete01:16

Tensile Strength Considerations of Concrete

561
Considering the tensile strength of concrete involves recognizing that the theoretical strength of cement paste can be up to a thousand times higher than what is observed in practical applications. This significant discrepancy is largely attributed to the presence of microscopic cracks within the concrete. These cracks tend to amplify stress at their tips when a load is applied, a phenomenon explained by Griffith's theory of brittle fracture.
The dimensions and shape of a concrete specimen...
561

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new era for oral peptides: SNAC and the development of oral semaglutide for the treatment of type 2 diabetes.

Reviews in endocrine & metabolic disorders·2022
Same author

Editorial Cycles and Continuity of Diabetes Care.

Diabetes care·2022
Same author

Efficacy of liraglutide added to sodium-glucose cotransporter-2 inhibitors in type 2 diabetes, stratified by baseline characteristics: Post-hoc analysis of LIRA-ADD2SGLT2i.

Diabetes, obesity & metabolism·2021
Same author

Improving Management of Type 2 Diabetes Using Home-Based Telemonitoring: Cohort Study.

JMIR diabetes·2021
Same author

Insulin glargine 300 units/mL for the treatment of individuals with type 2 diabetes in the real world: A review of the DELIVER programme.

Diabetes, obesity & metabolism·2021
Same author

A Lesson From 2020: Public Health Matters for Both COVID-19 and Diabetes.

Diabetes care·2021

Related Experiment Video

Updated: Feb 10, 2026

Fixation and Operational Method for Abdominal Massage in T2DM Mice
05:57

Fixation and Operational Method for Abdominal Massage in T2DM Mice

Published on: March 7, 2025

793

Combination Glucose-Lowering Therapy Plans in T2DM: Case-Based Considerations.

Lawrence Blonde1, Susana Dipp2, Daniel Cadena3

  • 1Frank Riddick Diabetes Institute, Department of Endocrinology, Ochsner Medical Center, New Orleans, LA, USA. lblonde@ochsner.org.

Advances in Therapy
|May 20, 2018
PubMed
Summary

Most patients with type 2 diabetes mellitus (T2DM) eventually need multiple medications. This study explores combination pharmacotherapy selection for T2DM management, guiding treatment choices based on patient factors and guidelines.

Keywords:
Antihyperglycemic agentsDPP-4 inhibitorsFixed dose combinationGLP-1 receptor agonistsGlycemic controlSGLT2 inhibitorsType 2 diabetes mellitus

More Related Videos

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
14:56

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

9.5K
Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
04:54

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Published on: June 2, 2023

2.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

Fixation and Operational Method for Abdominal Massage in T2DM Mice
05:57

Fixation and Operational Method for Abdominal Massage in T2DM Mice

Published on: March 7, 2025

793
The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
14:56

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

9.5K
Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
04:54

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Published on: June 2, 2023

2.0K

Area of Science:

  • Endocrinology
  • Pharmacology
  • Internal Medicine

Background:

  • Type 2 diabetes mellitus (T2DM) is a progressive condition requiring pharmacotherapy beyond lifestyle interventions for most patients.
  • Current guidelines emphasize individualized glycemic goals and treatment selection for T2DM.
  • Declining pancreatic beta-cell function necessitates multi-agent therapy as T2DM progresses.

Purpose of the Study:

  • To illustrate the application of current treatment guidelines and algorithms for selecting non-insulin-based combination therapy in T2DM.
  • To demonstrate individualized treatment selection for T2DM patients in primary care settings.
  • To discuss the comparative advantages of different combination therapy approaches for T2DM.

Main Methods:

  • Review of current T2DM treatment guidelines and algorithms.
  • Presentation of two case studies illustrating combination therapy selection.
  • Discussion of patient-specific and drug-specific factors influencing treatment choices.

Main Results:

  • Metformin is the recommended initial pharmacotherapy for T2DM when appropriate.
  • Selection of additional agents depends on atherosclerotic cardiovascular disease, patient factors (age, hypoglycemia risk, comorbidities), and drug factors (hypoglycemia risk, weight effects, cost).
  • Combination therapy can be administered as multi-pill, single-pill, or oral/injectable combinations.

Conclusions:

  • Individualized selection of antihyperglycemic agents is crucial for effective T2DM management.
  • Combination therapy is often necessary due to the progressive nature of T2DM.
  • Case presentations highlight practical application of guidelines for T2DM pharmacotherapy.