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Updated: Feb 10, 2026
06:36
A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
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Potential vascular mechanisms in an ex vivo functional pig bladder model
Uzoma A Anele1, Paul H Ratz2, Andrew F Colhoun1
1Division of Urology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Neurourology and Urodynamics
|May 20, 2018
Summary
The bladder may have an intrinsic autoregulation mechanism to maintain oxygenation during low blood flow. This suggests chronic ischemia could be a key factor in developing underactive bladder (UAB).
Area of Science:
- Urology
- Physiology
- Vascular Biology
Background:
- Chronic ischemia is implicated in underactive bladder (UAB) pathophysiology.
- The role of transient ischemia and bladder autoregulation in UAB remains unclear.
Purpose of the Study:
- To investigate the role of transient ischemia in bladder function.
- To determine if the bladder possesses an autoregulatory mechanism similar to other vital organs.
Main Methods:
- An ex vivo functional porcine bladder model was utilized.
- Bladders were perfused, and flow rates were sequentially decreased to assess perfusion pressure and tissue oxygenation during simulated filling.
Main Results:
- A linear relationship between flow rate and perfusion pressure was observed until flow dropped below 5 mL/min.
- Vascular resistance decreased at lower flow rates, while tissue oxygen levels (pO2) remained stable after an initial drop, suggesting autoregulation.
Conclusions:
- Findings suggest an intrinsic bladder autoregulatory mechanism exists, allowing for relative ischemia during normal function.
- Impaired autoregulation due to chronic or complete ischemia may contribute to detrusor underactivity, emphasizing early intervention.
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