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Complement Factor H as a potential atherogenic marker in chronic Chagas' disease.

K C F Lidani¹, T L Sandri^1,2, F A Andrade¹

¹Laboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.

Parasite Immunology

|May 20, 2018

Summary

Plasma levels of complement Factor H (FH) correlate with metabolic issues in chronic Chagas' disease (CD). Higher FH links to dyslipidemia and inflammation, suggesting a role in immune and metabolic dysregulation in CD patients.

Keywords:

Trypanosoma cruzi Chagas’ disease complement inflammation

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Area of Science:

Immunology
Cardiology
Metabolic Disorders

Background:

Chronic Chagas' disease (CD) involves complex immune and metabolic alterations.
The role of complement Factor H (FH) in the pathogenesis of CD, particularly cardiac involvement and metabolic parameters, remains under-investigated.

Purpose of the Study:

To investigate the association between plasma Factor H (FH) levels and cardiac involvement, inflammatory, and cardiometabolic parameters in patients with chronic Chagas' disease (CD).

Main Methods:

Plasma FH levels were measured in 80 chronic CD patients.
Cardiometabolic parameters (glycemic index, lipidogram, BMI, blood pressure) and inflammatory marker (uCRP) were analyzed.
Cardiac function (LVEF) was assessed via echocardiography.
Statistical analyses included Mann-Whitney and Spearman correlation tests.

Main Results:

FH levels positively correlated with triglycerides, LDL-C, total cholesterol, uCRP, and BMI.
FH levels negatively correlated with HDL-C.
Dyslipidemic patients exhibited higher FH levels compared to normolipidemic patients.
No significant difference in FH levels was found between different clinical forms of chronic CD.

Conclusions:

Complement Factor H (FH) is associated with cardiometabolic and inflammatory parameters in chronic Chagas' disease (CD).
The alternative complement pathway may link immune response and metabolic disorders in CD.
FH plays a potential immunoregulatory role in the context of metabolic disturbances in chronic CD.