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UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis

Junrong Wang1, Cong Ye1, Junbao Liu1

  • 1Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, PR China.

Biochemical and Biophysical Research Communications
|May 20, 2018
PubMed

Insights

Long non-coding RNAs (lncRNAs) like Urothelial Carcinoma Associated 1 (UCA1) impact ovarian cancer chemoresistance. UCA1 promotes paclitaxel resistance by regulating ABCB1 via miR-129, suggesting a new therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Dysregulated long non-coding RNAs (lncRNAs) are implicated in cancer chemoresistance.
  • The specific mechanisms of lncRNAs in ovarian cancer (OC) paclitaxel (PTX) resistance require further elucidation.

Purpose of the Study:

  • To investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel resistance in ovarian cancer.

Main Methods:

  • Compared UCA1 expression in PTX-resistant vs. parental OC cells.
  • Assessed the effect of UCA1 knockdown on PTX sensitivity and apoptosis.
  • Investigated the regulatory axis involving UCA1, miR-129, and ABCB1.

Main Results:

  • UCA1 was significantly upregulated in PTX-resistant OC cells.
  • UCA1 knockdown sensitized OC cells to PTX by enhancing apoptosis.
  • UCA1 silencing increased PTX sensitivity by de-repressing ABCB1 through sponging miR-129.

Conclusions:

  • A novel UCA1/miR-129/ABCB1 regulatory axis contributes to PTX resistance in OC.
  • This axis represents a potential therapeutic target for overcoming chemoresistance in ovarian cancer.
Keywords:
ABCB1Ovarian cancerPaclitaxel resistanceUCA1miR-129

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