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Updated: Feb 10, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
Enhanced antibacterial activity, mechanical and physical properties of alginate/hydroxyapatite bionanocomposite film
Bahador Safikhani Gholizadeh1, Foad Buazar2, Seyed Mehdi Hosseini1
1Department of Fisheries and Aquaculture, Khorramshahr University of Marine Sciences and Technology, P.O. Box 669, Khorramshahr, Iran.
Abstract:
The effect of hydroxyapatite nanoparticles (HA NPs) contents on the antibacterial activity, physical, and mechanical properties of sodium alginate (SA) film was scrutinized. The samples were prepared via incorporation of three different concentrations of HA NPs (1%, 3%, and 5%) into alginate solution at ambient temperature. In all SA/HA matrices, HA NPs demonstrated considerable bactericidal activity against foodborne pathogen during 12 days. The highest antibacterial effect of SA film was obtained in the presence of 5%HA NPs content and showed 3 CFU/mg reduction. In comparison to pristine alginate, different HA NPs additives enhanced elongation, tensile strength and moisture content of the nanocomposite films. Moreover, water solubility and water vapor permeability of the bionanocomposite were considerably reduced by 50% as the concentration of HA NPs content up to 5%.
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