Related Experiment Video
Updated: Feb 10, 2026

Measuring Influenza Neutralizing Antibody Responses to AH3N2 Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells
Published on: November 22, 2017
Using Google Trends and ambient temperature to predict seasonal influenza outbreaks
Yuzhou Zhang1, Hilary Bambrick1, Kerrie Mengersen2
1School of Public Health and Social Work, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Background:
The discovery of the dynamics of seasonal and non-seasonal influenza outbreaks remains a great challenge. Previous internet-based surveillance studies built purely on internet or climate data do have potential error.
Methods:
We collected influenza notifications, temperature and Google Trends (GT) data between January 1st, 2011 and December 31st, 2016. We performed time-series cross correlation analysis and temporal risk analysis to discover the characteristics of influenza epidemics in the period. Then, the seasonal autoregressive integrated moving average (SARIMA) model and regression tree model were developed to track influenza epidemics using GT and climate data.
Results:
Influenza infection was significantly corrected with GT at lag of 1-7 weeks in Brisbane and Gold Coast, and temperature at lag of 1-10 weeks for the two study settings. SARIMA models with GT and temperature data had better predictive performance. We identified autoregression (AR) for influenza was the most important determinant for influenza occurrence in both Brisbane and Gold Coast.
Conclusions:
Our results suggested internet search metrics in conjunction with temperature can be used to predict influenza outbreaks, which can be considered as a pre-requisite for constructing early warning systems using search and temperature data.
Related Concept Videos
Seasoning of Wood
Achieving equilibrium moisture content is the goal of seasoning; this is the point where the wood's moisture content stabilizes to align with the moisture levels of the surrounding environment. Proper...
Biological Clocks and Seasonal Responses
Current Trends in Nursing I
Current Trends in Nursing II
Steps in Outbreak Investigation
Predicting Molecular Geometry

