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The Scandinavian multicenter photopatch study 1980-1985: final report
P Thune1, C Jansén, G Wennersten
1Ullevaal Hospital, Oslo, Norway.
Photo-Dermatology
|December 1, 1988
Summary
Photopatch testing on 1993 patients revealed polymorphic light eruption (PLE) as the most common photodermatosis. Secondary aggravation of skin diseases and photocontact dermatitis were also significant findings in sun-related skin conditions.
Area of Science:
- Dermatology
- Photobiology
- Allergology
Background:
- Photodermatoses affect a significant number of patients presenting to dermatology clinics.
- Understanding the specific causes and triggers of these conditions is crucial for diagnosis and management.
Purpose of the Study:
- To analyze the results of photopatch testing in a large cohort of patients with suspected photodermatosis.
- To identify the most common causes of sun-related skin conditions and contact sensitivities.
Main Methods:
- Photopatch testing was conducted on 1993 patients across 16 dermatology clinics in Scandinavia between 1980 and 1985.
- Standard series, including the SPDRG standard series, were used to assess reactions to various substances and UV light.
Main Results:
- Polymorphic light eruption (PLE) was the most frequent diagnosis (38%).
- Secondary aggravation of existing skin diseases occurred in 16% of patients.
- Photocontact dermatitis (11%) and contact dermatitis (10%) were identified, with specific allergens like musk ambrette and para-aminobenzoic acid noted as common photosensitizers.
Conclusions:
- Photopatch testing is a valuable diagnostic tool for identifying causes of photodermatosis and contact sensitivities.
- Specific allergens and photosensitizers were identified, informing potential avoidance strategies.
- Further investigation into photosensitization mechanisms and sunscreen sensitivity is warranted.