Related Experiment Video
Updated: Feb 10, 2026

A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
Published on: August 14, 2013
Total mandibulectomy defect in the setting of chronic bisphosphonate use
Ameya A Jategaonkar1, Arvind K Badhey1, Mofiyinfolu Sokoya2
1The New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States.
Abstract:
Bisphosphonates are among several drugs known in modern medicine to have a potentially deleterious effect on the mandible with chronic use. While purportedly causing a necrotic reaction in the bone, the complete mechanism is not fully elucidated yet as cases are quite rare in the general public. Despite the esoteric nature of this entity, patients suffering from bisphosphonate induced necrosis have a complicated and prolonged course often involving varying degrees of mandibular debridement with severe cases requiring reconstruction. In this report, we present the unique case of a patient with a progressive mandibular osteonecrosis requiring complete mandibulectomy and fibula flap reconstruction.
More Related Videos
Related Concept Videos
Lumber Defects
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...
Setting Time of Cement
Total Voids in Concrete
Specialized Care Centers and Settings-II
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
PPE Use in Healthcare Settings I: Donning
PPE Use in Healthcare Settings II: Doffing

