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Renal Pre-Competitive Consortium (RPC2): discovering therapeutic targets together
Mark Tomilo1, Heather Ascani1, Barbara Mirel2
1Internal Medicine, University of Michigan, Ann Arbor, MI 48103, USA.
Drug Discovery Today
|May 21, 2018
Summary
Researchers formed the Renal Pre-Competitive Consortium (RPC^2) to improve kidney disease outcomes. This collaboration uses systems biology and shared data to accelerate the discovery of new therapies for renal disease.
Area of Science:
- Nephrology
- Genomics
- Systems Biology
Background:
- Patient outcomes in kidney disease have stagnated for 20 years.
- Identifying novel risk factors, progression markers, and therapies for renal disease is crucial.
- Genome-scale data analysis offers a platform to understand the molecular basis of kidney disease.
Purpose of the Study:
- To establish an academic-industry consortium to advance drug development for kidney diseases.
- To overcome challenges in expertise and resources for large-scale genomic studies in renal disease.
- To accelerate the identification of molecular targets for novel kidney disease therapies.
Main Methods:
- Formation of the Renal Pre-Competitive Consortium (RPC^2).
- Collaboration between academia and the pharmaceutical industry.
- Application of a systems biology approach to analyze genome-scale data.
Main Results:
- Establishment of a consortium to share expertise and resources.
- Initiation of molecular target identification efforts for kidney diseases.
- Development of a platform for understanding the molecular basis of renal disease.
Conclusions:
- The Renal Pre-Competitive Consortium (RPC^2) strategy facilitates collaborative research in kidney disease.
- This approach aims to accelerate the development of effective therapies for renal disease.
- Shared efforts in systems biology and genomics are vital for advancing nephrology research.
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