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Updated: Feb 10, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Separation of chloroform from a dilute solution using a cyclic peptide nanotube: A molecular dynamics study
Xin Zhao1, Jian Fen Fan1, Xia Lan Si1
1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Abstract:
This work firstly explored the potential application of a cyclic peptide nanotube (CPNT) in the separation of chloroform from a dilute solution. Four hydrophobic CPNTs of 8 × (WL)4,5 and 8 × (AL)4,5 all exhibit excellent adsorption characteristics to chloroform. The CPNT diameter, side chain structures and the concentration of chloroform in a solution all affect the adsorption characteristics of chloroform. CHCl3 molecules are overwhelmingly adsorbed on the surfaces of these CPNTs as a cluster, and sporadically reside inside the channels, consistent with the chloroform's potentials of mean force (PMFs) inside and outside the channels. The distribution characteristics, molecular orientations and interactions with the surroundings of chloroform inside and outside four CPNTs embedded in individual dilute CHCl3/water solutions were analyzed in detail, providing referable information of the adsorption characteristics of a hydrophobic CPNT to chloroform.
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