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Formulation techniques for high dose dry powders.

Ashlee D Brunaugh1, Hugh D C Smyth2

  • 1University of Texas at Austin, College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, 2409 West University Avenue, Austin, TX 78712, United States.

International Journal of Pharmaceutics
|May 21, 2018
PubMed
Summary
This summary is machine-generated.

Dry powder inhalers (DPIs) offer promising lung drug delivery for local and systemic diseases. This review details formulation strategies to overcome challenges in delivering high-dose powders via DPIs.

Keywords:
Carrier-freeDry powder formulationDry powder inhalersHigh dose deliveryInhalationParticle engineering

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Pulmonary Medicine

Background:

  • Dry powder inhalers (DPIs) are established for delivering bronchodilators, anticholinergics, and corticosteroids to the lungs.
  • There is increasing interest in using DPIs for high-dose lung administration of antimicrobial, antiviral, and osmotic agents.
  • Pulmonary drug delivery via DPIs is advantageous for both local lung conditions and systemic diseases.

Purpose of the Study:

  • To review formulation techniques for high-dose DPIs.
  • To address physiological and physicochemical challenges in high-dose pulmonary drug delivery.
  • To provide insights into overcoming barriers for effective high-dose powder delivery to the lungs.

Main Methods:

  • Literature review of formulation strategies for DPIs.
  • Analysis of physiological and physicochemical challenges in high-dose pulmonary delivery.
  • Synthesis of information on techniques to enhance powder properties for inhalation.

Main Results:

  • Various formulation techniques exist to manage high-dose DPI challenges.
  • Understanding powder properties is crucial for successful high-dose pulmonary delivery.
  • Specific methods address issues like powder flow, aerosolization, and lung deposition.

Conclusions:

  • Formulation science is key to unlocking the potential of high-dose DPIs.
  • Overcoming formulation barriers enables broader therapeutic applications for DPIs.
  • Advanced formulation techniques are essential for effective high-dose pulmonary drug administration.