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Updated: Feb 10, 2026

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Published on: December 16, 2013

pH-Dependent silica nanoparticle dissolution and cargo release.

Giorgia Giovaninni¹, Colin J Moore², Andrew J Hall¹

¹Medway School of Pharmacy, University of Kent, Central Ave, Chatham Maritime, Kent, ME4 4TB, United Kingdom.

Colloids and Surfaces. B, Biointerfaces

|May 21, 2018

Summary

This summary is machine-generated.

Microporous silica nanoparticles show pH-responsive dissolution, degrading at pH 6-7.4 but not pH 4. This makes silica nanoparticles suitable for oral drug delivery, with tunable release profiles based on precursor materials.

Keywords:

Dissolution Drug delivery Dye release Intracellular Microporous Nanoparticle Oral delivery Silica

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Last Updated: Feb 10, 2026

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

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Published on: December 16, 2013

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Published on: February 8, 2017

Area of Science:

Nanomaterials Science
Drug Delivery Systems
Biocompatible Materials

Background:

Microporous silica nanoparticles (NPs) are explored for drug delivery.
Understanding NP dissolution is crucial for predicting in vivo performance.
Biologically relevant pH conditions impact nanomaterial stability.

Purpose of the Study:

To investigate the pH-dependent dissolution of silica NPs.
To evaluate silica NPs as potential oral drug delivery vehicles.
To correlate NP composition with drug release kinetics.

Main Methods:

Silica NPs synthesized using tetraethoxysilane and ethyl triethoxysilane precursors.
NP dissolution studied at pH 4, 6, and 7.4.
Characterization using electron microscopy, UV-vis, fluorimetry, and dynamic light scattering (DLS).

Main Results:

Silica NPs degraded at pH 6 and 7.4, but remained stable at pH 4.
Dissolution was visualized as surface defects and hollows via electron microscopy.
Ethyl triethoxysilane-based NPs showed burst release; tetraethoxysilane-based NPs showed sustained release.

Conclusions:

Silica NPs exhibit pH-responsive dissolution, ideal for oral drug delivery.
Varying organosilane precursors allows tuning of NP dissolution and drug release rates.
Silica NPs offer an adaptable platform for pH-triggered drug release applications.