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Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction
Qing Kuang1, Ning Xue1,2,3, Jing Chen1,2,3,4
1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
American Journal of Nephrology
|May 21, 2018
Summary
Plasma hydrogen sulfide (H2S) levels are lower in chronic kidney disease (CKD) patients and correlate with reduced kidney function and cardiac dysfunction, suggesting H2S plays a role in CKD progression and cardiovascular complications.
Area of Science:
- Biochemistry
- Nephrology
- Cardiology
Background:
- Chronic kidney disease (CKD) is linked to reduced hydrogen sulfide (H2S) levels.
- The precise role of H2S in CKD pathogenesis and cardiovascular disease (CVD) association requires further investigation.
Purpose of the Study:
- To measure endogenous H2S plasma levels across different CKD stages.
- To explore the relationship between H2S, CKD progression, and cardiovascular parameters.
Main Methods:
- Spectrophotometry was used to quantify plasma H2S in 157 CKD patients and 37 healthy controls.
- Serum levels of homocysteine (Hcy), cardiac troponin T (cTnT), and N-terminal pro B type natriuretic peptide were measured.
- Echocardiography assessed left ventricular ejection fraction (LVEF) to evaluate cardiac function.
Main Results:
- CKD patients exhibited significantly lower plasma H2S compared to controls (7.32 ± 4.02 vs. 14.11 ± 5.24 μmol/L).
- Plasma H2S positively correlated with estimated glomerular filtration rate (eGFR) and negatively with indoxyl sulfate.
- Lower H2S levels were associated with decreased LVEF and elevated cTnT, indicating cardiac dysfunction.
Conclusions:
- Plasma H2S levels decline with decreasing eGFR in CKD patients.
- Reduced H2S may contribute to cardiac dysfunction and cardiovascular complications in CKD.
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